Heparin quizlet

Decrease in vitamin K activity. An expected response to heparin therapy. Possible heparin induced thrombocytopenia (HIT) Possible heparin induced thrombocytopenia (HIT) Possible signs of HIT include a decrease in platelets 5-10 days after heparin therapy, a decrease in platelet count 30-50% from baseline, and new onset thrombosis.

Heparin quizlet. Study with Quizlet and memorize flashcards containing terms like Therapeutic anticoagulant for treatment and prevention of thrombosis • Extracted from porcine intestinal mucosa or beef lung, Heterogeneous mixture of sulfated mucopolysaccharides •2,000 - 30,000 Daltons •Binds to AT III, Enhances its ability to inactivate thrombin, Xa and other serine …

Pharmacologic class. antithrombotics. expected pharmacological action. potentiates the inhibitory effect of antithrombin on factor Xa and thrombin. In low dosages, prevents the conversion of prothrombin to thrombin by its effects on factor Xa. Higher doses neutralize the thrombin, preventing the conversion of fibrinogen to fibrin. therapeutic use.

Study with Quizlet and memorize flashcards containing terms like What are Heparin's Adverse Effects: Life-Threatening (3) Common S/S (1), Trade Names of Heparin (2), Routes of Heparin and more. Find step-by-step Chemistry solutions and your answer to the following textbook question: Heparin Interactions Heparin, a highly negatively charged glycosaminoglycan, is used clinically as an anticoagulant. It acts by binding several plasma proteins, including antithrombin III, an inhibitor of blood clotting. The $1:1$ binding of heparin to antithrombin III seems to cause a conformational ...A 65-year-old woman comes to the emergency department complaining of chest pain and shortness of breath.Her symptoms began three hours ago. Past medical history is notable for hypertension and alcoholic liver disease.Upon arrival, her temperature is 37.8°C (100.0°F), pulse is 102/min, blood pressure is 142/75 mmHg, and respiratory rate is 21/min. Swelling and erythema is observed in the ...Heparin-induced thrombocytopenia (HIT) is characterized by. Click the card to flip 👆. 1) a decrease in the platelet count of more than 50% from the highest platelet count value after the start of heparin. 2) an onset 5 to 10 days after the start of heparin. 3) hyper-coagulability. 4) presence of heparin-dependent, platelet-activating IgG ...Study with Quizlet and memorize flashcards containing terms like 1. The nurse would assess which laboratory value to determine the effectiveness of intravenous heparin? A. Complete blood count (CBC) B. Activated partial thromboplastin time (aPTT) C. Prothrombin time (PT) D. Blood urea nitrogen (BUN), 2. A patient who has been anticoagulated with warfarin (Coumadin) is admitted with ...Use low-molecular-weight heparin (LMWH). ANS: B. Discontinue the heparin infusion. All heparin is discontinued when HIT is diagnosed. The patient should be instructed to never receive heparin or LMWH. Warfarin is usually not given until the platelet count has returned to 150,000/µL. The platelet count does not drop low enough in HIT for a ...

Study with Quizlet and memorize flashcards containing terms like A patient has been prescribed warfarin (Coumadin) in addition to a heparin infusion. The patient asks the nurse why he has to be on two medications. The nurse's response is based on which rationale? a. The oral and injection forms work synergistically. b. The combination of heparin and an oral anticoagulant results in fewer ...Heparin Nursing Implications. Assess bleeding & hemorrhage signs; Observe for hematomas, ecchymosis, or inflammation; Assess for additional/ increased thrombosis. Heparin Pt Teach. Instruct pt not to use NSAID's/ aspirin. Study with Quizlet and memorize flashcards containing terms like Heparin trade name, Heparin Class, …A typical aPTT value is 30 to 40 seconds. If you get the test because you're taking heparin, you'd want your PTT results to be more like 120 to 140 seconds, and your aPTT to be 60 to 80 seconds. If your number is higher than normal, it could mean several things, from a bleeding disorder to liver disease.Study with Quizlet and memorize flashcards containing terms like What are Heparin's Adverse Effects: Life-Threatening (3) Common S/S (1), Trade Names of Heparin (2), Routes of Heparin and more.Plan to prepare and cook the brisket the day before you serve it. This way it’ll give the beef time to release its juices so you can use them to make the sauce. Also, once the juic...

Study with Quizlet and memorize flashcards containing terms like heparin unfractionated, low-molecular-weight heparin, A client with a history of pulmonary emboli is taking warfarin daily. The nurse teaches the client about foods that are appropriate to consume when taking this medication. The nurse evaluates that the client needs further teaching when the client makes which statement? A ... Study with Quizlet and memorize flashcards containing terms like What are Heparin's Adverse Effects: Life-Threatening (3) Common S/S (1), Trade Names of Heparin (2), Routes of Heparin and more. fresh frozen plasma. reversal by PROTAMINE SULFATE (1mg per 100 units of heparin via slow IV push) What is HIT. HIT is more dangerous and it is caused by IgG heparin immune complex, attack the heparin platelet factor 4 complex. Platelet count decreased to < 100,000 or by 50% of baseline platelet. Onset 3-15 days following start of UFH.Study with Quizlet and memorize flashcards containing terms like pharmacologic, route, Reason for giving this drug and more. ... HIT - heparin induced thrombocytopenia → dangerous, its not due to toxicity; antibodies that form to the heparin and result in destruction in platelets ...Study with Quizlet and memorize flashcards containing terms like Heparin Therapy, Mast cell, Unfractionated Heparin (UH) and more.Study with Quizlet and memorize flashcards containing terms like Anticoagulants, enhances antithrombin activity against factor Xa, Prevent and treat DVT Anticoagulation in pts w/ unstable angina, MI and more. ... Heparin. 7 terms. djb646. Aspirin. 4 terms. anao665. Apixaban. 8 terms. JenniferWine15. Other sets by this creator. Tetracycline ...

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Study with Quizlet and memorize flashcards containing terms like A female client calls the nurse at the clinic and reports that ever since the vein ligation and stripping procedure was performed, she has been experiencing a sensation as though the affected leg is falling asleep. The nurse should make which response to the client? 1, "Apply warm packs to the leg." 2."Keep the leg elevated as ...unfractionated heparin. long sting polysaccharide chains, adversely effects use by tissues, can inactivate both factor Xa & thrombin. low molecular weight heparin. shorter string polysaccharide chains, easier for tissue to use it, can only inactivate factor Xa. heparin adverse effects. hemorrhage (most common), neurological injury (from ...Problem 3: Your patient's recent PTT is 42. According to protocol, you need to increase the Heparin drip by 2 units/kg/hr and administer 30 units/kg IV bolus. You will recheck the PTT in 6 hours. The patient is currently receiving a Heparin drip at 16 units/kg/hr from a bag that reads 25,000 units/250 mL.Study with Quizlet and memorize flashcards containing terms like Units, subcut or IV, Serious injuries and death when misused and more. ... T/F Heparin sodium for injection and heparin lock flush solution can be used interchangeabbly. Two. How many nurses must always check the doses of Herparin before its administered? high-alert medication.Study with Quizlet and memorize flashcards containing terms like Heparin protocol is prescribed for a client weighing 90 kg. Per protocol, the heparin loading dose is 60 units/kg IV rounded to the nearest 100 units, with a maximum loading dose of 4,000 units. The heparin vial is labeled 5,000 units/ml. How many ml should the nurse administer? (Enter …

Diluent: Dilute 25,000 units of heparin in 250-500 mL of 0.9% NaCl or D5W. Premixed infusions are already diluted and ready to use. Admixed solutions stable for 24 hr at room temperature or if refrigerated. Premixed infusion stable for 30 days once overwrap removed. Concentration: 50-100 units/mL. fresh frozen plasma. reversal by PROTAMINE SULFATE (1mg per 100 units of heparin via slow IV push) What is HIT. HIT is more dangerous and it is caused by IgG heparin immune complex, attack the heparin platelet factor 4 complex. Platelet count decreased to < 100,000 or by 50% of baseline platelet. Onset 3-15 days following start of UFH. Activated partial thromboplastin time (aPTT) measures. measures changes in blood clotting factors, except for factor VII. During heparin therapy, the aPTT should be maintained at. at 1.5-2.5x's the control or baseline. normal control (heparin) 25-35 seconds. Theraputic heparin values. 45-70 seconds.Study with Quizlet and memorize flashcards containing terms like What does heparin combine with? What clotting factors does this inactivate?, What does heparin inhibit the conversion of?, How is heparin given? and more.Updated on April 30, 2024. By Gil Wayne BSN, R.N. Heparin is a critical medication that nurses must understand to ensure patient safety. Learn why it’s …Study with Quizlet and memorize flashcards containing terms like causes of thrombocytopenia, drug causes of thrombocytopenia, Type 1 HIT and more. ... -5-10 days after heparin exposure -can occur abruptly in patients with recent heparin exposure (esp: < 30 days) platelet count results from type 2 HIT. decreases by 50% or less.Study with Quizlet and memorize flashcards containing terms like Inappropriate formation of platelets or fibrin clots that obstructs blood vessels is called: a. thrombophilia. b. thrombosis. c. embolus. d. factor V Leiden., Which is the cause for most strokes and heart attacks in the United States? a. Hemorrhage b. Thrombocytopenia c. Cancer d. Consequences of thrombotic events, All are ...Drug Doses Exam 3. 24 terms. somyia28. Preview. Terms in this set (6) Study with Quizlet and memorize flashcards containing terms like heparin action, heparin use, heparin complications and more.Study with Quizlet and memorize flashcards containing terms like The nurse is caring for a patient with type 2 heparin-induced thrombocytopenia (HIT). The nurse understands that this disorder has which characteristic? Formation of thrombi Spontaneous epistaxis Elevated prothrombin times Massive peripheral ecchymoses, The nurse is caring for a patient with type 2 heparin-induced ...

The thrombocytopenia that occurs with immune-mediated HIT is related to the formation of heparin-antibody complexes. These complexes release a substance known as platelet factor 4. Platelet factor 4 attracts heparin molecules, forming immunogenic complexes that adhere to platelet and endothelial surfaces.

Study with Quizlet and memorize flashcards containing terms like The nurse is scheduled to administer the following medications at 0900: heparin subcutaneous, cefazolin IVPB, and atenolol po. The morning labs are platelets 150,000 mcL, WBC 10,000 mcL, APTT 100 seconds. Which is the nurse's priority in this situation?, A 73-year-old client receiving …Study with Quizlet and memorize flashcards containing terms like Blood coagulates to form a blood clot through a complex series of steps involving all of the following substances, EXCEPT: a) clotting factors b) platelets c) white blood cells d) thromboplastin, Warfarin (Coumadin, Jantoven) is _____. A) measured in milligrams B) given orally C) given intravenously D) all of the above ...Start studying Heparin. Learn vocabulary, terms, and more with flashcards, games, and other study tools. fresh frozen plasma. reversal by PROTAMINE SULFATE (1mg per 100 units of heparin via slow IV push) What is HIT. HIT is more dangerous and it is caused by IgG heparin immune complex, attack the heparin platelet factor 4 complex. Platelet count decreased to < 100,000 or by 50% of baseline platelet. Onset 3-15 days following start of UFH. Study with Quizlet and memorize flashcards containing terms like T/F: it's the nurse's responsibility to order PTT labs after initiation and any rate change, PTTs are draw every ___ hours after initiation and after any rate change, for patients who require a hold directed by the calculator, the 6 hour ptt time starts at the time of ____ and more.Study with Quizlet and memorize flashcards containing terms like A patient is placed on heparin, and the nurse acknowledges that heparin is effective for ...Study with Quizlet and memorize flashcards containing terms like Heparin is a ___-alert medication, Low-molecular weight heparin medications, Average heparin flush dose strength: and more.

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Study with Quizlet and memorize flashcards containing terms like Which patients below would be at a HIGH risk for developing adverse effects of Heparin drug therapy? Select all that apply: a) 55 yr old male who is post op day 1 from brain surgery b) 45 yr old female with a pulmonary embolism c) 36 yr old male with active peptic ulcer disease 43 yr old female with uncontrolled atrial ...Study with Quizlet and memorize flashcards containing terms like Generic Name, Trade Name, Classification and more. ... History of hypersensitivity to heparin, active ...Study with Quizlet and memorize flashcards containing terms like Why is Low-Molecular-Weight Heparin (LMWH) easier to use than unfractionated heparin?, How do LMWH molecules compare to unfractionated heparin molecules?, Which LMWHs are approved for use in the United States? and more.Study with Quizlet and memorize flashcards containing terms like 1. Heparin is an anticoagulant. What family of anticoagulant medications does this drug belong to? A. Direct thrombin inhibitors B. Indirect thrombin inhibitors C. Vitamin K antagonists D. Factor Xa inhibitors, 2. Which statement below BEST describes how Heparin works as an anticoagulant?Heparin pharmacology nursing NCLEX review for nursing students! This review will break down what you need to know for your pharmacology exams about the medication Heparin. Heparin is an anticoagulant that is used to treat and/or prevent blood clots. It is vital the nurse knows how the drug works, side effects, how to monitor the aPTT, and education to provide to the patient etc.PT 18 to 24 seconds is therapeutic (1.5 - 2 times of control) INR 2 - 3 is therapeutic (INR most accurate) Timing of warfarin effects. effects may take up to 8-12 hours and full effect is achieved in 3-5 days. Study with Quizlet and memorize flashcards containing terms like Heparin, Heparin adverse effects, Heparin overdose/toxicity and more.Heparin method of administration. Heparin is given subcutaneous or IV and should never be given IM. Heparin can be given as a bolus (IV injection of a drug over a period of minutes either diluted or undiluted) prior to starting a continuous IV heparin drip. When given subcutaneous (SC) Heparin is given most commonly into the abdomen and should ...Created by. hanahhutzler. Study with Quizlet and memorize flashcards containing terms like What is the mechanism of action of Heparin?, What is the indication for use of Heparin?, What will neutralize Heparin? and more. ….

Anticoagulants: Heparin Videos, Flashcards, High Yield Notes, & Practice Questions. Learn and reinforce your understanding of Anticoagulants: Heparin.Study with Quizlet and memorize flashcards containing terms like A nurse is monitoring a client who is undergoing anticoagulant therapy with Heparin. Which of the following findings should the nurse identify as a possible indication of hemorrhage? (yellow sclera, elevated BP, rapid pulse, or stool change), A client has an acute ischemic cerebrovascular event due to a thrombus in a cerebral vessel.PRINCIPAL STRATEGIC ASSET MANAGEMENT STRATEGIC GROWTH FUND INSTITUTIONAL CLASS- Performance charts including intraday, historical charts and prices and keydata. Indices Commodities...Heparin is an anticoagulant (blood thinner) that prevents the formation of blood clots. Heparin is used to treat and prevent blood clots caused by certain medical conditions or medical procedures. It is also used before surgery to reduce the risk of blood clots. Do not use heparin injection to flush (clean out) an intravenous (IV) catheter.Heparin, also known as unfractionated heparin (UFH), is a medication and naturally occurring glycosaminoglycan. Heparin is a blood anticoagulant that increases the activity of antithrombin. It is used in the treatment of heart attacks and unstable angina. It can be given intravenously or by injection under the skin. Its anticoagulant properties make it useful to prevent blood clotting in blood ...Study with Quizlet and memorize flashcards containing terms like 1. IV 2. subcutaneously (DVT prophylaxis), IV heparin, hemorrhage thrombocytopenia osteoporosis (chronic use) and more.a condition in which the patient developes antibodies against heparin and leads to drop in platelets and increases risk of clot formation characterized by a drop in platelet count - absolute platelet drop to <150,000 or >50% drop in platelet count from baseline can be life threatening and requires immediate discontinuationStudy with Quizlet and memorize flashcards containing terms like 1. Heparin is an anticoagulant. What family of anticoagulant medications does this drug belong to?, 2. Which statement below BEST describes how Heparin works as an anticoagulant, 3. Which patients below would be at a HIGH risk for developing adverse effects of Heparin drug therapy? Select all that apply: and more. Heparin quizlet, Study with Quizlet and memorize flashcards containing terms like UFH & LMWH Indications, UFH, SubQ dosing q 12H and more. ... - Dosing for heparin SC: 1-1.5 mg IV protamine/100 units hep; 25-50 mg slow IV bolus then remaining as continuous infusion over 8-16 hrs or repeat IV bolus - Protamine ADE: Hypotension, bradycardia, heparin rebound ..., Heparin Drip Calculation Problems. Learn how to solve heparin drip calculations. These practice problems for heparin drip calculations will test your ability to calculate: new flow …, Preview. Unit 4 Chapter 6. maryelizabethrobin. Preview. Characteristics of Shock. marvelousKafa. Preview. Study with Quizlet and memorize flashcards containing terms like what class of drug is heparin?, what is the action of heparin?, what are some situations where heparin is used? and more., Study with Quizlet and memorize flashcards containing terms like classified as a "high-alert drug", heparin is a potent _____ that prevents clot formation and blood coagulation., dosages usually expressed in and more., The two sides met today to hash out security for the April 27 summit, which will see a North Korean leader cross into the South for the first time since at least 1950. The date app..., Study with Quizlet and memorize flashcards containing terms like Following heparin treatment for a pulmonary embolism, a client is being discharged with a prescription for warfarin (Coumadin). In conducting discharge teaching, the nurse advises the client to have which diagnostic test monitored regularly after discharge? A. Perfusion scan. B. Prothrombin Time (PT/INR)., Study with Quizlet and memorize flashcards containing terms like A patient is placed on heparin, and the nurse acknowledges that heparin is effective for ..., Study with Quizlet and memorize flashcards containing terms like IV doses, SQ doses, dont give SQ shots within 2 inches of and more. ... low molecular weight heparin-SQ in abdomen-rotate sites. Upgrade to remove ads. Only $35.99/year. About us. About Quizlet; How Quizlet works; Careers; Advertise with us; Get the app; For students. Flashcards;, DVT/PE treatment. Bolus dosing: 80 units/kg (10,000 units max) Initial infusion rate: 18 units/kg/h. Acute Myocardial Infarction/Unstable Angina. Bolus dosing: 60-70 units/kg (5000 units max) Initial infusion rate: 12-15 units/kg/hr (1000 units/hr max) Acute Myocardial Infarction with thrombolytic therapy. Bolus dosing:60 units/kg (4000 units max), Study with Quizlet and memorize flashcards containing terms like Which of the following is the chemical antagonist of heparin:, What do we use to reverse the effects of warfarin (Coumadin)?, We use enoxaparin (Lovenox) in the hospital to prevent: and more., Heparin-induced thrombocytopenia (HIT) is a severe complication that can occur in patients exposed to any form or amount of heparin products.[1] A fall in platelet counts and a hypercoagulable state characterize HIT. Patients who experience HIT may also develop thromboembolic complications that are associated with morbidity and mortality. This is a significant burden since heparin is widely ..., Study with Quizlet and memorize flashcards containing terms like Why are hemostatics used? Can you name some?, Name three surgical procedures that usually require heparin ready on the back table. In what strengths., How does oral anticoagulant therapy effect the patient about to undergo a surgical procedure? and more., Study with Quizlet and memorize flashcards containing terms like You are reviewing the chart of a PT who is receiving heparin therapy for a DVT. Which intervention should the RN anticipate taking if the PTs aPTT is 96 seconds? 1. Increase heparin infusion rate by 2mL/hr 2. Continue monitor the heparin infusion as prescribed 3. Request a prothrombin time PT 4. Stop the heparin infusion, You are ..., Start studying What drug is used to counteract Heparin. Learn vocabulary, terms, and more with flashcards, games, and other study tools., Study with Quizlet and memorize flashcards containing terms like Which is a major complication of thrombocytopenia? 1. Fatigue 2. Weakness 3. Hemorrhage 4. Abdominal pain, Which type of thrombocytopenia may be observed in a patient who has a viral infection? 1. Hereditary thrombocytopenia 2. Heparin-induced thrombocytopenia (HIT) 3. Immune thrombocytopenic purpura (ITP) 4. Thrombotic ..., Study with Quizlet and memorize flashcards containing terms like Why is Low-Molecular-Weight Heparin (LMWH) easier to use than unfractionated heparin? Select all that apply. It has a shorter half-life. It can be given using a fixed dosage. It can be given as long-term therapy. It can be given intravenously in the hospital. It does not require activated partial thromboplastin time (aPTT ..., What pregnancy category is heparin? C. What education should you give to your patient regarding heparin? - prevent excess blood loss, so use electric razors, sunscreen, bug spray. - avoid NSAIDs because they increase risk of bleeding. Study with Quizlet and memorize flashcards containing terms like What routes can heparin be given by?, What ..., Study with Quizlet and memorize flashcards containing terms like The most common anticoagulant used for apheresis procedures is: a. Heparin. b. Sodium fluoride. c. Warfarin d. Citrate., Therapeutic cytapheresis has a primary role in treatment of patients with: a. Sickle cell disease and acute chest syndrome. b. Systemic lupus erythematosus to remove immune complexes. c. Leukemia to help ..., 9th Edition • ISBN: 9780323399098 Jennifer Yeager, Kathleen DiMaggio, Linda McCuistion, Mary Winton. 359 solutions. 1 / 6. Study with Quizlet and memorize flashcards containing terms like give a dose of heparin via an IV push bolus, bolus, the one you will give in the IV push bolus and more., Study with Quizlet and memorize flashcards containing terms like When is a heparin or saline lock used in IV administration A. When a traditional IV bag is used B. When medication or IV access might be needed later on .C. When fluid is likely to be administered D. When IV administration will not involve a vein, You have just administered nitroglycerin to a 68 year old patient, within a few ..., 1)Hemorrhagic Complications: adrenal, gut 2) Heparin Induced Thrombocytopenia and heparin induced thrombosis: generation of antiheparin platelet factor 4 antibodies. These antibodies activate platelets and endothelial cells 3) osteoporosis following chronic administration 4) alopecia following long term usage. Study with Quizlet and memorize ..., Study with Quizlet and memorize flashcards containing terms like A client is receiving a continuous intravenous infusion of heparin sodium to treat deep vein thrombosis. The client's activated partial thromboplastin time (aPTT) is 65 seconds. The nurse anticipates that which action is needed? 1. Discontinuing the heparin infusion 2. Increasing the rate of the heparin infusion 3. Decreasing the ..., Study with Quizlet and memorize flashcards containing terms like Which statement describes the cause of heparin-induced thrombocytopenia (HIT)?, Which predisposing factors related to disseminated intravascular coagulation (DIC) are related to tissue damage?, Which is the most commonly seen acquired thrombocytopenia? and more., Study with Quizlet and memorize flashcards containing terms like Heparin, Enoxaparin(Lovenox) Classification, Heparin, Enoxaparin(Lovenox) Uses, Heparin, Enoxaparin(Lovenox) Route:Usual Dosage and more., Plavix. Platelet aggregation inhibitor. Tablet, 75mg and 300mg. 1. Acute ST and non-ST segment elevation myocardial infarction: 300-600 mg po load- ing dose, followed by 75 mg po daily in combination with aspirin. 2. Thrombosis prevention in arteriosclerotic vascular disease, following stroke, in peripheral arterial occlusive disease: 75 mg po ..., Study with Quizlet and memorize flashcards containing terms like A nurse is administering subcutaneous heparin to a client who is at risk for deep vein thrombosis. Which of the following actions should the nurse take?, A nurse is caring for a client who has a new prescription for tamoxifen. The nurse should recognize that tamoxifen has which of the following therapeutic effects?, A nurse is ..., Therapeutic Range. Prolonged PTT. -We are going to increase the drip until we get a prolonged PTT inside the TR. PTT. Partial Thromboplastin Time. -Want this to be a little elevated. -Want this to prolong this bleeding because we don't want the patient to clot. Does Heparin break up clots? NO., A, B, E. Which location for a superficial venous thrombosis is the most common? A. Top of the foot. B. Across the knees. C. Groin area. D. Behind the knees. D. A postpartum patient is diagnosed with a pulmonary embolism and is receiving a heparin drip. The prescription reads as follows: 20,000 units heparin/500 mL of D5W infusing at 22 mL/h., Heparin common SE's. Fever, chills, hives. Heparin rare SE's. Bronchiospasms, nausea, vomiting, shock. Heparin long term use SE's. Osteoporosis, alopecia, priapism, hyperkalemia. Heparin Induced Thrombocytopenia (HIT) Immune mediated drug induced disorder, 5-14 days after initiation of Tx, platelets drop greater than 50% or around/less than ..., Study with Quizlet and memorize flashcards containing terms like what drug class is heparin, what is heparins mechanism of action?, what are the indications for giving heparin? and more., Study with Quizlet and memorize flashcards containing terms like The nurse would assess which laboratory value to determine the effectiveness of intravenous heparin? A) Complete blood count (CBC) B) Activated partial thromboplastin time (aPTT) C) Prothrombin time (PT) D) BUN, A patient who has been anticoagulated with warfarin (Coumadin) is admitted with gastrointestinal bleeding., Study with Quizlet and memorize flashcards containing terms like how is protamine sulfate administered?, action of protamine sulfate, asses for allergies of what before giving protamine sulfate? and more. ... rebound effects of heparin can occur as late as how many hours after therapy? 18. black box warning for protamine sulfate. no single dose ..., Heparin method of administration. Heparin is given subcutaneous or IV and should never be given IM. Heparin can be given as a bolus (IV injection of a drug over a period of minutes either diluted or undiluted) prior to starting a continuous IV heparin drip. When given subcutaneous (SC) Heparin is given most commonly into the abdomen and should ...